【学习及工作经历】

教育经历：

2006.08 -2011.03        美国匹兹堡大学  博士

2003.09 -2006.06        兰州大学     硕士

1999.09 -2003.06   兰州大学 学士

工作经历：

2012.06-                      山东大学 教授

2011.03 -2012.04   美国哈佛大学  博士后



【主讲课程】

【研究领域和兴趣】

 (a) 催化不对称氧化碳氢官能团化

        (b) 简单烯烃的氧化官能团化

（2）活性天然产物的全合成及构效关系研究

（3） 具有生物活性的小分子试剂的设计和发现研究（针对肿瘤、真菌及阿兹海默症）

【主要论著】

2017年

(26) Long, H.; Wang, G.; Lu, R.; Xu, M.; Zhang, K.; Qi, S.; He, Y.; Bu, Y.; Liu, L.* Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds, Org. Lett. 2017, 19, 2146.

(25) Wan, M.; Shu, S.; Li, Y.; Liu, L.* Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An "Acetal Pool" Strategy, Angew. Chem. Int. Ed. 2017, 56, 5116.

2016年

(24) Wang, G.; Mao, Y.; Liu, L.* Diastereoselectively Complementary C-H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines. Org. Lett. 2016, 18, 6476.

(23) Wang, G.; Sun, S.; Mao, Y.; Xie, Z.; Liu, L.* Chromium (II) Catalyzed Enantioselective Arylation of Ketones. Beilstein. J. Org. Chem. 2016, 12, 2771. (Invited by Professor Tehshik P Yoon for Thematic Series "Strategies in Asymmetric Synthesis")

(22) Sun, Y.; Wang, G.; Chen, J.; Liu, C.; Cai, M.; Zhu, R.*; Huang, H.*; Li, W.*; Liu, L.* A Practical Oxidative C-H Functionalization of N-Carbamoyl Tetrahydro-beta-Carbolines with Diverse Potassium Trifluoroborates. Org. Biomol. Chem. 2016, 14, 9431.

(21) Xie, Z.; Zan, X.; Sun, S.; Pan, X.; Liu, L.* Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes. Org. Lett. 2016, 18, 3944.  

(20) Xie, Z.; Liu, X.; Liu, L.* Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes. Org. Lett. 2016, 18, 2982. (Highlight by Synfacts)

(19) Sun, S.; Liu, L.* Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals. Synthesis 2016, 48, 2627 (Invited for specific topic "Asymmetric Synthesis" by Erick Carreira)

(18) Xie, Z.; Jia, J.; Liu, X.; Liu, L.* Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes. Adv. Synth. Catal. 2016, 358, 919.  

(17) Liu, G.; Qian, J.; Hua, J.; Cai, F.; Li, X.; Liu, L.* An Economical Synthesis of Substituted Quinoline-2-Carboxylates through the Potassium Persulfate-Mediated Cross-Dehydrogenative Coupling of N-Aryl Glycine Derivatives with Olefins. Org. Biomol. Chem. 2016, 14, 1147.

2015年

(16) Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 2015, 13, 11561. (Highlight by Synfacts)

(15) Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem. Commun. 2015, 51, 13953. (Highlight by Synfacts)  

(14) Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Commun. 2015, 51, 10691.

(13) Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org. Lett. 2015, 17, 2396. (Top 20 most downloaded article for May2015)

(12) Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem. 2015, 13, 5710.

(11) Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 2015, 17, 1684.(Highlight by Synfacts)

(10) Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 2015, 54,6012. (Highlight by Synfacts)

2014年

(9) Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp³)-HFunctionalization. Org. Lett. 2014, 16, 5988.

(8) Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 2014, 55, 6899.

(7) Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 2014, 53,13845. (Selected as “hot paper” by Angew Chem)

(6) Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* Aneconomic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO₂. Org. Biomol. Chem. 2014, 12,7774.

(5) Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na₂S₂O₈. Tetrahedron 2014, 70,3447.

(4) Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 2014, 55, 2879.

(3) Xie, Z. Y.; Liu,L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 2014, 53,3904. (Highlight by Chinese J Org Chem)

(2) Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.*Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 2014, 53, 543. (selectedas “Hot Paper” by Angew Chem/Highlightby Synfact, 2014, 341)

2013年

(1) Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H.X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp³ C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 2013, 78, 3104.

哈佛大学博士后研究工作 （2011-2012）

(13) Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 2012, 14,2262.

匹兹堡大学攻读博士期间工作（2006-2011）
(12) Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 2010, 49, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)

(11) Liu, L.;Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2010, 49, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)

(10) Liu, L.;Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.

(9) Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO₂ as A StoichiometricOxidant. Org. Lett. 2010, 12, 4686.

(8) Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 2009, 11, 3152. (Highlightedin SynFacts 2009, 998)

(7) Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2008, 47, 4184.

兰州大学攻读硕士期间工作（2003-2006）

(6) Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition ofPhenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)–Copper(II)Complex. Synlett. 2006, 8, 1245.

(5) Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.

(4) Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derivedβ-Amino Alcohol. Tetrahedron: Asymmetry 2004, 15, 3757.

(3) Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005, 347, 243.

(2) Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 2004, 15, 3155.

(1) Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 2005, 35, 1819.



【科研项目】

在研项目

1. 霍英东青年教师基金                 2016-2019 主持

2. 深圳市科技计划项目                 2015-2017 主持

3. 山东省自然科学基金“杰出青年基金” 2015-2017 主持

4. 国家自然科学基金（面上项目） 2015-2018 主持

5. 山东大学交叉学科培育基金 2015-2017  主持

6. 广西师范大学国家重点实验室开放基金              2016-2018 主持

结题项目

1. 教育部“新世纪优秀人才”支持计划 2014-2016 主持

2. “齐鲁青年学者”特聘教授科研启动资金         2012-2016 主持

3. 国家自然科学基金(青年基金) 2013-2015 主持

4. 山东省优秀中青年科学家科研奖励基金 2013-2015 主持

【科研成果】

人才计划和获奖情况

1. 霍英东教育基金奖励（2016年）

2. Thieme Chemistry Journal Award (2016年)

3. 山东省自然科学基金“杰出青年基金”(2014年)

4. 教育部“新世纪优秀人才”（2013年）

5. “齐鲁青年学者”（2012年）

6. 中国科学院奖学金（2005年）

【所获专利】

【联合培养情况】

【拟招收研究生情况】