有机化学
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高洪银
发布时间:2018年09月01日 08:10    作者:化学与化工学院    点击:[]

【个人简介】

姓名: 高洪银

出生年月:  19837

学历:博士研究生

职称:   “齐鲁青年学者特聘教授(博士生导师)

单位:    有机化学研究所

研究方向现代有机合成方法学研究、活性药物小分子(中间体)合成及生物活性探究

地址:  山东省济南市山大南路27号新化学楼525

电话:0531-88361236

Email:  hygao@sdu.edu.cn

【学习及工作经历】

2016.11 -                 山东大学    教授

2015.05 - 2016.10   美国莱斯大学  博士后   导师:Prof. Laszlo Kurti

2012.01 - 2015.05   美国德州大学西南医学中心  博士后    导师:Prof. Laszlo Kurti

2011.09 - 2011.12    北京大学深圳研究生院    研究助理    导师:赵劲教授

2006.09 - 2011.07    华东师范大学    博士    导师:张俊良教授

2001.09 - 2006.07    泰山学院     学士    导师:孙一峰教授


【主讲课程】

有机化学                             

【研究领域和兴趣】


1)多官能团取代的药物活性小分子的设计、合成及生物活性探究

2)新型官能团化反应试剂的设计、开发与应用

3)金属催化的串联反应

4)自由基化学

5)高价碘化学


                                                                                           

【主要论著】

山东大学独立研究工作:


2. KaitlynLovato,  Lirong Guo,  Qing-Long Xu, Fengting Liu,  MuhammedYousufuddin,d  Daniel H. Ess,*  László Kürti* and Hongyin Gao* “Transition metal-free direct dehydrogenative arylation ofactivated C(sp3)–H bonds: synthetic ambit and DFT reactivity predictions.”Chem.Sci. 2018,DOI: 10.1039/c8sc02758g. (Link)


1. HairuiYuan, Thirupathi Nuligonda, Hongyin Gao, Chen-Ho Tung and Zhenghu Xu* “Copper-Catalyzed IntermolecularCarbene Insertion into S-S bond of Benzenesulfonothioate.” Org. Chem. Front. 2018, 5, 1371-1374. (Link)

研究生及博士后期间工作:

15.   ZheZhou, Zhiwei Ma, Nicole Erin Behnke1, Hongyin Gao and László Kürti.* “Non-Deprotonative Primary andSecondary Amination of (Hetero)Arylmetals.” J. Am. Chem. Soc. 2017, 139, 115-118.(Link)

14.   Hongyin Gao,Zhe Zhou, Doo-Hyun Kwon, James Coombs, Steven Jones, Nicole Erin Behnke1,Daniel H. Ess*, László Kürti.* “Rapid Heteroatom-Transfer toArylmetals Utilizing Multifunctional Reagent Scaffolds.”Nat. Chem. 2017,9, 681-688.(Link) Thispaper was highlighted by C&EN (2016, 94 (48).) <Link>and X-Mol <Link> on December 7th, 2016.

13.   Hongyin Gao,#Qing-Long Xu, # CraigKeene, Muhammed Yousufuddin, Daniel H. Ess,LászlóKürti.*“PracticalOrganocatalytic Synthesis of Functionalized Non-C2-SymmetricalAtropisomeric Biaryls.”Angew. Chem. Int. Ed. 2016, 55, 566-571. (Hot Paper) (Link) Thispaper was highlighted by C&EN (Chemical and Engineering News2015,93(48), 37.). <Link># Contributed equally.

12.   Hongyin Gao,Qing-Long Xu, Craig Keene, László Kürti.*“Scalable,Transition-Metal-Free Direct Oxime O-Arylation:Rapid Access to O-Arylhydroxylaminesand Substituted Benzo[b]furans.” Chem. Eur. J. 2014, 20, 8883-8887. (Link)

11.  Hongyin Gao, Qing-Long Xu, Muhammed Yousufuddin, Daniel H.Ess, László Kürti.*“Rapid Synthesis of Fused N-Heterocycles byTransition-Metal-Free Electrophilic Amination of Arene C-H Bonds.” Angew. Chem. Int.Ed. 2014,53, 2701-2705. (Hot Paper)(Link) This paper was highlighted by SYNFACTS (Synfacts 2014, 10(4), 351.). <Link>

10.  Jawahar L Jat, Mahesh P. Paudyal, Hongyin Gao, Qing-Long Xu, Muhammed. Yousufuddin, DeepaDevarajan, Daniel H. Ess, László Kürti,*J. R. Falck.* “DirectStereospecific Synthesis of Unprotected N-Hand N-Me Aziridines from Olefins.”Science 2014, 343, 61-65.(Link) This paper was highlighted by Science, <Link>Nature Chemistry,<Link> Angewandte Chemie International Edition, <Link>Chemical and Engineering Newsand Chemistry World.

9.     Qing-Long Xu, Hongyin Gao, Daniel H.Ess, LászlóKürti.* “Aerobic,Transition-Metal-Free, Direct and Regiospecific Mono-α-Arylation of Ketones:Synthetic Studies and Mechanism by DFT Calculations.” J. Am. Chem. Soc. 2013, 135, 14048-14051.(Link)

8.     Gong-Qiang Li, Hongyin Gao, Craig Keene, Michael Devonas, Daniel H. Ess,LászlóKürti.* “OrganocatalyticAryl-Aryl Bond-Formation: An Atroposelective [3,3]-Rearrangement Approach to BINAM Derivatrives.” J. Am. Chem. Soc. 2013, 135, 7414-7417.(Link)

7.      Hongyin Gao, Daniel H. Ess, M.Yousufuddin,  László Kürti.* “Transition-Metal-FreeDirect Arylation: Synthesis of Halogenated 2-Amino-2’-Hydroxy-1,1’-Biaryls andMechanism by DFT Calculations.”  J. Am. Chem. Soc. 2013, 135, 7086-7089. (Cover Paper)(Link) Thispaper was highlighted by JACS (J. Am. Chem. Soc. 2013, 135, 7081.),<Link> SYNFACTS(Synfacts 2013, 9(8), 879.) <Link>and C&EN (Chemical and Engineering News 2013,91(21), 40.).<Link>


6.     Hongyin Gao, Junliang Zhang.“CatalyticCascade Reactions”, Chap 6, 225-282. FirstEdition. Edited by Peng-Fei Xu and Wei Wang. JohnWiley & Sons, Inc. 2014.


5.      Hongyin Gao, Junliang Zhang.*“Cationic Rhodium(I)-Catalyzed Regioselective TandemHetero- cyclization/ [3+2] Cycloaddition of 2-(1-Alkynyl)-2-alken-1-ones withAlkynes.”Chem. Eur. J. 2012, 18, 2777-2782.(Link)

4.      Hongyin Gao, Xingxing Wu, Junliang Zhang.*“Gold(I)-Catalyzed Highly Diastereo-selective Tandem Heterocyclization/[3+2]Cycloaddition: Synthesis of Highly Substituted Cyclopenta[c]furan.”Chem. Eur. J. 2011,17, 2838-2841.(Link)

3.      Hongyin Gao, Xingxing Wu, Junliang Zhang.*Exo/endoselectivity-control in Lewis-acid catalyzed tandem hetero-cyclization/formal[4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkyn-yl)-2-alken-1-onesand 1,3-diphenylisobenzofuran.” Chem. Commun. 2010, 46,8764-8766. (Link)

2.     Hongyin Gao, XiaoliZhao, Yihua Yu, Junliang Zhang.* “Highly Substituted Furo[3,4-c]azepines by Gold(I)-Catalyzed Diastereoselective Tandem Double Heterocyclizationsand 1,2-Alkyl Migration.” Chem. Eur. J. 2010, 16, 456-459.(Link) This paper was highlighted by SYNFACTS ( Synfacts 2010, 3, 285.).<Link>

1.      Hongyin Gao, JunliangZhang. “A Dramatic Substituent Effect in Silver(I)-Catalyzed RegioselectiveCyclization of ortho-AlkynylarylAldehyde Oxime Derivatives.” Adv. Synth. Catal. 2009, 351, 85-88.(Link)


 

【科研项目】

(1)     国家自然科学基金(青年项目)                     在研、主持

(2)     山东省自然科学基金(面上项目)                   在研、主持

(3)     山东大学“齐鲁青年学者”科研启动经费             在研、主持



   

【科研成果】

【所获专利】

1. Hongyin Gao, László Kürti, Zhe Zhou.Amination and Hydroxylation of Arylmetal Compounds.” (US Provisional filed on 5/5/2016 by Rice University; IP Application # 62/366,483).


2. Hongyin Gao, László Kürti.Transition Metal Free Methods of Synthesis of Biaryl Compounds.” (US Provisional patent filed on 11/9/2015 by Rice University. Now Converted: PCT/US2016/061628).


3. Carolyn L. Cannon,         Hongyin Gao,         László Kürti, Kush Nimish Shah, Parth Nimish Shah.                 Biaryl Compounds as Antimicrobial and Chemotherapeutic Agents.” (US Provisional patent filed on 9/16/2015 jointly by Rice University and Texas A&M University. Now Converted: PCT/US2016/061607).                                                                                                

【联合培养情况】

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【拟招收研究生情况】

热烈欢迎对有机化学感兴趣的本科生、硕士生、博士生和博士后加入本课题组!


                                                                                           

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