分析化学
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徐晓文
发布时间:2018年09月01日 08:11    作者:化学与化工学院    点击:[]

【个人简介】

姓名:徐晓文

性别:男

出生年月:1985年11月

单位:分析化学研究所

职称:副教授

地址:化学新楼320室

E-mail:xuxw@sdu.edu.cn



【学习及工作经历】

2003.09 – 2007.07 青岛科技大学 高分子科学与工程学院 工学学士

2007.09 – 2010.07 青岛科技大学化学与分子工程学院

                              中国科学院长春应用化学研究所电分析化学国家重点实验室

                              联合培养理学硕士 (导师:焦奎教授、杨秀荣院士)

2010.09 – 2013.11 中国科学院长春应用化学研究所 电分析化学国家重点实验室

                              理学博士(导师:杨秀荣院士)

2013.12 – 2015.04 Florida International University 化学与生物化学系 研究助理

2015.06 – 2018.08 山东大学 化学与化工学院 助理研究员

2018.09 –至今 山东大学 化学与化工学院 副教授



【主讲课程】

仪器分析实验

无机及分析化学实验



【研究领域和兴趣】

基于DNA识别功能的传感;

基于DNA-纳米粒子体系的生物分析;

DNA逻辑门及链取代反应研究。

【主要论著】

Xiurong Yang,* Xiaolei Wang, Hui Zhu,Xiaowen Xu, Noble Metal Nanoparticles in Bioanalysis. In Functional Nanoparticles for Bioanalysis, Nanomedicine, and Bioelectronic Devices; American Chemical Society: Washington, DC, 2012; Volume 1, Chapter 9.

【科研项目】

6.山东大学青年学者未来计划资助 2018 – 2023 主持,在研

5.国家自然科学基金青年基金 2018 – 2020 主持,在研

4.山东省自然科学基金博士基金 2017 – 2019 主持,在研

3.山东省博士后创新项目专项资金 2017 – 2019 主持,在研

2.中国博士后科学基金面上资助 2016 – 2018 主持,结题

1.山东大学基本科研业务费 2015 – 2017 主持,结题

【科研成果】

18. Xiaowen Xu, Pingping Zhang, Ruiyuan Zhang, Nan Zhang*, Wei Jiang*, A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells. Chemical Communications, 2019, 55, 6026-6029.

17. Xiaowen Xu, Lei Wang, Wanling Cui, Wei Jiang*, Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity. Talanta, 2019, 194, 282-288.

16.Xiaowen Xu, Lei Wang, Desong Zhu, Yan Wang*, Wei Jiang*, Protein binding protection in combination with DNA masking for sensitive and reliable transcription factor detection. Talanta, 2018, 186, 293-298.

15.Xiaowen Xu, Lei Wang, Wanling Cui, Wei Jiang*, An integrated and restructive probe mediated strand displacement amplification strategy for sensitive and specific DNA methyltransferase activity detection. Sensors and Actuators B, 2018, 266,124-130.

14.Xiaowen Xu, Lei Wang, Kan Li, Qihong Huang, Wei Jiang*, A smart DNA tweezer for detection of human telomerase activity. Analytical Chemistry, 2018, 90, 3521-3530.

13. Rui Wang, Lei Wang,Xiaowen Xu*, Wei Jiang*, An enzyme-free and label-free fluorescence biosensor for microRNA detection based on cascade amplification of DNAzyme-powered three-dimensional DNA walker and hybridization chain reaction. Sensors and Actuators B, 2018, 268, 287-292.

12. Pingping Zhang, Lei Wang, Haiyan Zhao,Xiaowen Xu*, Wei Jiang*, Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity, Analytica Chimica Acta, 2018, 1001, 119-124.

11. Wenjing Chen, Lei Wang, Rong He,Xiaowen Xu*, Wei Jiang*, Convertible DNA ends-based silver nanoprobes for colorimetric detection human telomerase activity. Talanta, 2018, 178, 458-463.

10.Xiaowen Xu, Lei Wang, Yushu Wu, Wei Jiang*, Uracil removal-inhibited ligase reaction in combination with catalytic hairpin assembly for the sensitive and specific detection of uracil-DNA glycosylase activity. Analyst, 2017, 142,4655-4660.

9.Xiaowen Xu, Haiping Wei, Wei Jiang*, A target triggered proximity combination-based fluorescence sensing strategy for adenosine detection. Analyst, 2017, 142, 2247-2252.

8. Haixiang Yu(#),Xiaowen Xu(#), Pingping Liang, Kang Yong Loh, Bhargav Guntupalli, Daniel Roncancio, Yi Xiao*, A broadly applicable assay for rapidly and accurately quantifying DNA surface coverage on diverse particles. Bioconjugate Chemistry, 2017, 28, 933-943. (#: Co-first author)

7. Kan Li, Lei Wang,Xiaowen Xu*, Wei Jiang*, Label-free molecular beacons-based cascade amplification DNA machine for sensitive detection of telomeraseactivity. Talanta, 2017, 167, 645-650.

6.Xiaowen Xu, Lei Wang, Yongqi Huang, Wushuang Gao, Kan Li, Wei Jiang*, Model-guided interface probe arrangement for sensitive protein detection. Analytical Chemistry, 2016, 88, 9885-9889.

5.Xiaowen Xu, Xiurong Yang*, Reversion of DNA strand displacement with functional nucleic acids as toeholds. Chemical Communications, 2014, 50, 805-807.

4.Xiaowen Xu, Xiurong Yang*, Facile colorimetric detection of glucose based on an organic Fenton reaction. Analytical Methods (Inside cover), 2011, 3, 1056-1059.

3.Xiaowen Xu, Jia Zhang, Fan Yang, Xiurong Yang*, Colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles. Chemical Communications, 2011, 47, 9435-9437.

2.Xiaowen Xu, Juan Wang, Kui Jiao*, Xiurong Yang*, Colorimetric detection of mercury ion (Hg2+) based on DNA oligonucleotides and unmodified gold nanoparticles sensing system with a tunable detection range. Biosensors and Bioelectronics, 2009, 24, 3153-3158.

1.Xiaowen Xu, Juan Wang, Fan Yang, Kui Jiao*, Xiurong Yang*, Label-free colorimetric detection of small molecules utilizing DNA oligonucleotides and silver nanoparticles. Small, 2009, 5, 2669-2672.

【所获专利】

【联合培养情况】

【拟招收研究生情况】

2019年拟招收硕士研究生一名。欢迎本科生加入。

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