【个人简介】

姓名：张秋
性别：女
学历：博士
职称：副教授
研究类别：分析化学
工作单位：分析化学研究所

E-mail: zhangqiu@sdu.edu.cn

【学习及工作经历】

【主讲课程】

【研究领域和兴趣】

小分子化合物的抗癌效应及机制研究

【主要论著】

【科研项目】

（一）作为负责人主持的科研项目
1. 国家自然科学基金青年基金：对比羧基化多壁碳纳米管和羧基化石墨烯预暴露对乙型肝炎病毒所致肝损伤的作用研究（2014-2016）
2. 中国博士后第七批特别资助：不同表面修饰的碳纳米管暴露对小鼠继发乙型肝炎的影响（2014-2017）
3. 山东省自然科学基金青年基金：噻唑烷酮类小分子化合物选择性抗脑神经胶质瘤作用的机制研究（2013-2016）
4. 教育部博士点基金：羧基化多壁碳纳米管预暴露对乙型肝炎病毒感染所致小鼠肝损伤的影响及机制研究（2013-2016）
5. 教育部留学回国人员基金：新型噻唑烷酮化合物选择性抗脑神经胶质瘤作用的实验研究 （2014-2016）
6. 第54批博士后面上资助：多壁碳纳米管预暴露对小鼠乙型肝炎的影响及机制研究 （2013-2015）
7. 山东大学自主创新基金自由探索项目：新型噻唑烷酮类化合物选择性诱导非小细胞肺癌凋亡的机制研究 （2010-2012）
（二）参加的科研项目
1. 国家重大基础研究（973）课题：目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价（2010-2014） 主要参与者
2. 国家自然科学基金重大研究计划重点项目：典型纳米材料的生物毒性效应及调控研究（2012-2016） 参与者
3. 国家自然科学基金重大培育项目：选择性治疗耐药性肺癌的噻唑烷酮类小分子探针化合物的设计、合成及其体内外抗癌活性研究与机制探讨 （2010-2012） 主要完成人

【科研成果】

30. Zhiping Wang, Chunhui Li, Yan Mu, Zhang Lin, Anji Yi, Qiu Zhang*, Bing Yan*. Nanoadduct Relieves: Alleviation of Developmental Toxicity of Cr(VI) Due to Its Spontaneous Adsorption to Mg(OH)2 Nanoflakes. Journal of hazardous materials, 2015; 287:296-305.
29. Yan Mu, Yin Liu, Liwen Li, Cong Tian, Hongyu Zhou, Qiu Zhang*, Bing Yan*. The Novel Tubulin Polymerization Inhibitor MHPT Exhibits Selective Anti-tumor Activity against Rhabdomyosarcoma in vitro and in vivo. PlOS ONE, 2015; 10(3):e0121806.
28. Yin Liu, Fei Li, Ling Wu, Wenyi Wang, Hao Zhu, Qiu Zhang, Hongyu Zhou, Bing Yan*. Improving Both Aqueous Solubility and Anti-Cancer Activity by Assessing Progressive Lead Optimization Libraries. Bioorganic & Medicinal Chemistry Letters. 2015;25(9):1971-5.
27. Zhang Q, Zhai S, Li L, Li X, Jiang C, Zhang C, Yan B*. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model. J Pharmacol Sci. 2014;126(1):66-76.
26. Leng X, Zhang Q*, Chen Z, Wang D. Blocking TRAIL-DR5 signaling with soluble DR5 alleviates acute kidney injury in a severely burned mouse model. Int J Clin Exp Pathol. 2014;7(6):3460-8.
25. Jiao Q, Li L, Mu Q*, Zhang Q*. Immunomodulation of nanoparticles in nanomedicine applications. Biomed Res Int. 2014;2014:426028.
24. Zhang CK, Zhai SM, Li XE, Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, Zhang SS, Su GX, Zhang B, Yan B.* Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death & Disease 2014;5:1138.
23. Li Liwen; Liu Yin; Zhang Qiu; Zhou Hongyu; Zhang Yi; Yan Bing*. Comparison of Microtubule Damage-Triggered Cancer Cell Survival after Turning Kinase Dyrk1B On and Off. ACS Chemical Biology, 2014;9(3):731-42.
22. Zhang Q*, Li F. Combating P-glycoprotein-Mediated Multidrug Resistance Using Therapeutic Nanoparticles. Curr Pharm Des. 2013,19(37):6655-66.
21. Zhang Q, Zhai S, Li L, Li X, Zhou H, Liu A, Su G, Mu Q, Du Y, Yan B*. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochem Pharmacol. 2013; 86(3): 351-60.
20. Zhang Q, Liu X, Li X, Li C, Zhou H, Yan B. Antitumor activity of （2E，5Z）-5-（2-hydroxybenzylidene）-2-（（4-phenoxyphenyl）imino） thiazolidin-4-one， a novel microtubule-depolymerizing agent， in U87MG human glioblastoma cells and corresponding mouse xenograft model. J Pharmacol Sci. 2013，1(3): 223-31.
19.Sun J, Zhang Q, Wang Z, Yan B*. Effects of nanotoxicity on female reproductivity and fetal development in animal models. Int J Mol Sci. 2013;14(5): 9319-37.
18. Zhang C, Zhang Q, Zhang Y, Yan B*. Toward a Better Understanding of Pharmacokinetics of Nanomaterials. Curr Pharm Des. 2013;19(37):6667-80.
17. Leng X, Zhang Q（co-first author), Zhai X, Chen Z*. Local transplant of human umbilical cord matrix stem cells improves skin flap survival in a mouse model. Tohoku J Exp Med. 2012; 227(3): 191-7.
16. Mu QX, Su GX, Li LW, Gilbertson B, Yu L, Zhang Q, Sun Y-P, Yan B*. Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets. ACS Appl Mater Interfaces. 2012; 4(4), 2259-66.
15. Gao NN, Zhang Q, Mu QX, Bai YH, Li LW, Zhou HY, Butch ER, Powell TB, Snyder SE, Jiang GB, and Yan B*. Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NF-κB Activation and Reduces Its Immunotoxicity. ACS Nano. 2011; 5(6), 4581- 91.
14. Li LW, Zhang Q, Liu AF, Li, XE, Zhou HY, Liu Y, Yan B*. Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. J Am Chem Soc. 2011; 133(18), 6886-9.
13. Zhou QF, Dergunov SA, Zhang Y, Li X, Mu QX, Zhang Q, Jiang GB, Pinkhassik F, Yan B*. Safety profile and cellular uptake of biotemplated nanocapsules with nanometer-thin walls. Nanoscale. 2011; 136 (3), 872-7.

2007-2010
12. Zhang Q, Zhou HY, Zhai SM, Yan B*. Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities. Curr Pharm Des. 2010; 16(16):1826-42.
11. Zhang Q, Zhou HY, Yan B*. Reducing Nanotube Cytotoxicity Using a Nano-Combinatorial Library Approach. Carbon Nanotubes Methods Mol Biol. 2010; 625:95-107.
10. 李秀娥, 高素莲, 张秋*. 功能化多壁碳纳米管对NHFB 细胞的毒性研究. 山 东 大 学 学 报 (理学版). 2010: 45: 6-11.
9.张秋. HBV adr亚型体外感染肝细胞模型的建立.中国病理生理杂志. 2010; 26 (1): 200-2.
8.张秋. 慢性乙肝患者外周血单个核细胞TRAIL受体表达及其临床意义. 基础医学与临床. 2010; 30(3), 275-9.
7.张秋. HBV转染对TWEAK诱导凋亡的影响及IFN-γ对凋亡的调节. 中国病理生理杂志. 2010; 26 (2): 341- 4.
6．Q Zhang, Feng W, Zhou HY, Zhang B, Yan B*. Advances in Preclinical Small Molecules for the Treatment of Non-Small Cell Lung Cancer. Expert Opin Ther Patents. 2009; 19(6): 731-51. 2.
5. Yu YM, Zhang Q (co-first author), Mu QX, Zhang B, Yan B*. Exploring the Immunotoxicity of Carbon Nanotubes. Nanoscale Res Lett. 2008; 3(8), 271-7.
4. Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B*. A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Letters. 2008; 8(3), 859-65.
3.高宁宁，张颖，张秋*. 碳纳米管的免疫毒性研究. 环境化学学报. 2008; 27(6), 835-8.
2. Liang X, Liu Y（co-first author）, Zhang Q, Gao L, Han L, Ma C, Zhang L, Chen YH, Sun W. Hepatitis B Virus Sensitizes Hepatocytes to TRAIL-Induced Apoptosis through Bax. J Immunol. 2007, 78 (1):503-10.
1. Liu YG, Liu SX, Liang XH, Zhang Q, Gao LF, Han LH, Cao YL, Hou N, Du J, Sun WS. Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model. Biochem Biophys Res Commun. 2007, 352 (2): 329-34.

【联合培养情况】

【拟招收研究生情况】

• 拟招收硕士研究生1-2名