【学习及工作经历】

学士：山东大学

硕士：山东大学

博士：韩国国立昌原大学

博士后：香港科技大学

访问教授：德国海德堡大学

【主讲课程】

有机化学（本科双语）

药物合成（本科限选）

药物化学（硕研）

【研究领域和兴趣】

1. 活性天然产物及活性中药单体及其类似物的全合成；

2. 活性杂环化合物高效及环境友好的合成方法学；

3. 活性杂环化合物组合合成、小分子库构建及筛选；

【主要论著】

1). Zeyuan Zhang, Zhen Dai, Xinkun Ma,Yihan Liu, XiaojunMa, Wanli Li, Chen Ma*“Cu-Catalyzed One-potSynthesis of Fused Oxazepinone Derivatives via sp² C-H and O-H Cross-Dehydrogenative Coupling”

Org. Chem. Front., 3, 799-803, 2016.

2). Huanhuan Liu, Tianran Zhai, Shiteng Ding, Yalei Hou,Xiangyu Zhang, LeiFeng, and Chen Ma* “Direct and Metal-freeOxidative Amination of sp³ C-H Bonds for the Construction of2-Hetarylquinazolin-4(3H)-ones”

Org. Chem. Front., 3, 1096-1099, 2016.

3). Tiantian Duan, TianranZhai, Huanhuan Liu,Zilong Yan, Yue Zhao, Lei Feng, Chen Ma*“One-pot three-component synthesis of quinazolinesvia a copper-catalysed oxidativeamination reaction”

Org.Biomol. Chem., 14, 6561-6567, 2016.

4). Caixia Xie, LeiFeng, Wanli Li, Xiaojun Ma, Xinkun Ma, Yihan Liu, andChen Ma* “EfficientSynthesis of Pyrrolo[1,2-a]quinoxalines Catalyzed by BrønstedAcid throughCleavage of C-C Bond”

Org.Biomol. Chem., 14, 8529-8535, 2016.

5). Liu, H.; Duan, T.; Zhang, Z.;Xie, C.; Ma, C.*“One-Pot Synthesisof Pyrrolo[1,2-a]quinoxaline Derivativesvia a Copper-Catalyzed Aerobic Oxidative Domino Reaction”

Org.Lett., 17, 2932-2935, 2015.

6). Zhang, Z.; Xie, C.;Tan, X.; Song, G.; Wen, L.; Gao, H.; Ma, C.* “I₂-CatalyzedOne-pot Synthesis of Pyrrolo[1,2-a]quinoxalineand Imidazo[1,5-a]quinoxaline Derivatives via sp³ and sp² C-HCross-DehydrogenativeCoupling”

Org. Chem. Front., 2, 942-946 , 2015.

7). Tan, X.; Du, Y.; Yang, B.; Ma, C.* “Novel type of AIE materialas highly selective fluorenscent sensor for the detection of cysteine and glutathione”

RSCAdvances, 5, 55165-55169, 2015.

8). Wang, W.; Peng, X.; Qin, X.;Zhao, X.; Ma,C.*; Tung, C.; Xu, Z.* “Synthesis of Quinolinones withPalladium-Catalyzed Oxidative Annulation between Acrylamides and Arynes”

J. Org. Chem., 80, 2835-2841,2015.

9). Hu, F.; Xia, Y.; Ma, C.; Zhang, Y.; Wang, J.* “C–H bond functionalization based on metalcarbene migratory insertion”

Chem. Comm,51, 7986-7995, 2015.

10). Xie, C.; Zhang, Z.; Yang, B.;Song, G.; Gao, H.; Wen, L.; Ma, C.* “Anefficient iodine–DMSO catalyzed synthesis of quinoxaline derivatives”

Tetrahedron, 71, 1831–1837, 2015.

11). Yang, B.; Tan, X.; Guo, R.;Chen, S.; Zhang, Z.; Chu, X.; Xie, C.; Zhang, D.*; Ma,C.* “A Transition Metal-FreeOne-Pot Synthesis of Fused 1,4-Thiazepin-5(4H)-ones and Theoretical Study on S-N Type SmilesRearrangement Process”

J. Org. Chem., 79, 8040-8048,2014.

12). Fang, S.; Niu, X.; Zhang, Z.;Sun, Y.; Si, X.; Shan, S.; Wei, L.; Xu,A.; Feng, L.; Ma, C.* “A one-pot synthetic strategyfor construction of the dibenzodiazepine skeleton via a transition metal-free process”

Org. Biomol. Chem., 12, 6895-6900,2014.

13). Hu, F.; Xia, Y.; Ma, C.*; Zhang, Y.; Wang, J.* “Cu(I)-CatalyzedCross Coupling of Conjugated Ene-Yne-Ketones and Terminal Alkynes: Synthesis ofFuran-Substituted Allenes”

Org.Lett., 16, 4082-4085, 2014.

14). Hu, F.; Xia, Y.; Liu, Z.; Ma, C.*; Zhang, Y.; Wang, J.* “Palladium-catalyzedthree-component reaction of N-tosylhydrazone, norbornene and aryl halide”

Org. Biomol. Chem., 12, 3590–3593, 2014.

15). Fang, S.; Niu, X.; Yang, B.; Li,Y.; Si, X.; Feng, L.; Ma, C.* “One-PotSynthesis of Benzo[4,5]imidazo[1,2-a]quinazoline Derivatives via FacileTransition-Metal-Free Tandem Process”

ACS Combinatorial Science, 16, 328–332, 2014.

16). Niu, X.; Yang, B.; Fang, S.; Li, Y.; Zhang, Z.; Jia, J.; Ma, C.* “An efficientone-pot synthesis of 1,2,4-triazoloquinoxalines”

Tetrahedron, 70, 4657–4660, 2014.

17). Huang, A.; Chen, Y.; Zhou, Y.; Guo, W.; Wu,X.; Ma, C.* “An Efficient One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]quinoxalines viaCopper-CatalyzedProcess”

Org.Lett., 15, 5480–5483, 2013.

18). Li, Y.; Yang, B.; Sun, Y.; Wang, H.; Li, H.; Fang, S.;Niu, X.; Ma,C.* “Metal-Free Tandem CycloadditionStrategy for the Synthesis of Indolizines from Pyridine Derivatives andγ-Bromo-crotonates under Mild Conditions”

RSC Advances, 3, 21418–21423, 2013.3.708

19). Yang, B.; Huang, Z.; Guan, H.; Niu, X.; Liu, Y.; Fang, S.; Ma, C.* “Newroutes forthe synthesis of fused pyrrole scaffolds through transitionmetal-free tandem reactions”

TetrahedronLett., 54, 5994–5997, 2013.2.391

20). Yang, B.; Niu, X.; Huang, Z.; Zhao, C.; Liu, Y.; Ma, C.* “A novel kind of dimmer (excimer)-induced-AIE compound 2-phenylisothiazolo[5,4-b]pyridin-3(2H)-one as high selectivebisulfite anion probe”

Tetrahedron, 69, 8250–8254, 2013.

21). Huang, A.; Liu, H.; Ma, C.* “One-pot synthesis of 6H-benzo[b]benzo[4,5]imidazo[1,2-d][1,4]oxazines via copper-catalyzedprocess”

RSC Advances, 3, 13976–13982, 2013.

22). Niu, X.; Yang, B.; Li, Y.; Fang, S.; Huang, Z.;Xie, C.; Ma,C.* “A transition metal-free tandem process topyridazinopyrido[3,2-f][1,4]thiazepine-dionesvia Smiles rearrangement”

Org. Biomol. Chem., 11, 4102–4108, 2013.

23). Zhao, Y.; Bai, Y.; Zhang,Q.; Chen, Z.; Dai, Q.; Ma, C.* “A Facile Method for the Synthesis of Pyridazino[4,5-b][1,4]thiazine-diones via Smiles Rearrangement”

Tetrahedron Lett., 54, 3253–3255, 2013.

24). Hu, F.;Zhao,X.; Li, Y.; Feng, L.; Ma, C.* “Regioselective Synthesis of Phenoxathiine Derivatives underTransition Metal-Free Conditions”

Synthesis, 45, 966–970, 2013.2.443

25). Huang, A.; Ma,C.* “RecentProgress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines”

Mini-Reviews in MedicinalChemistry, 13 (4), 607–616, 2013.

26). Zhao, Y.; Dai, Q.; Chen, Z.; Zhang, Q.; Bai, Y.; Ma, C.* “One pot regioselectivesynthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles Rearrangement”

ACS Combinatorial Science, 15, 130–134, 2013.

27). Li, Y.; Zhan, C.; Yang, B.; Cao, X.; Ma, C.* “A one-pot transition metal-freetandem process to 1,4-benzodiazepine scaffolds”

Synthesis, 45,111–117, 2013.

28). Huang, A.; Feng, L.; Qiao, Z.; Yu, W.; Zheng, Q.; Ma, C.* “Synthesis ofpyrrolobenzoxazepinones by CuI/L-proline-catalyzedintramolecular couplingreactions”

Tetrahedron, 69, 642–646, 2013.

29). Liu, Y.; Zhang, X.; Ma, Y.; Ma,C.* “An Efficient C-C Bond Formation Reaction for the Synthesisof α-Arylated Ketones under Mild Conditions”

TetrahedronLett., 54, 402–405, 2013.

30). Zhao, Y.; Wu, Y.; Jia, J.; Zhang, D.*; Ma, C.* “A One-Pot Synthesis ofBenzo[1,4]thiazin-3(4H)-ones and Theoretical Study on S-N Type SmilesRearrangement Mechanism”

J. Org. Chem., 77,8501–8506, 2012.

31). Zhang, X.; Jia, J.; Ma,C.* “A one-pot regioselective synthesis ofbenzo[d]imidazo[2,1-b]thiazoles”

Org. Biomol. Chem., 10,7944–7948, 2012.

32). Zhan, C.; Jia, J.; Yang, B.; Huang, A.; Liu, Y.; Ma, C.* “A Tandem Coupling/SmilesRearrangement/Cyclization Approach to 1,4-Benzooxazinones or1,4-Pyridooxazinones under Mild Conditions”

RSC Advances, 2 (19), 7506–7512, 2012.

33). Liu, Y.; Ma, Y.; Zhan, C.; Huang, A.; Ma, C.* “One-Pot Synthesis of Fused Pyridazino[4,5-b][1,4]Oxazepiones via Smiles Rearrangement”

Synlett, 23, 255–258, 2012.2.463

34). Huang, A.; Qiao, Z.; Zhang, X.; Yu, W.; Zheng, Q.; Ma,Y.; Ma, C.* “A Transition metal-free Tandem Process to Pyrrolopyrazino[2,3-d]pyridazine-diones”

Tetrahedron, 68,906–912, 2012.

35). Huang, A.; Liu, F.; Zhan, C.; Liu Y.; Ma, C.* “One-pot synthesis ofpyrrolo[1,2-a]quinoxalines”

Org. Biomol.Chem., 9, 7351–7357, 2011.

36). Liu, Y.; Chu, C.; Huang, A.; Zhan, C.; Ma,Y.; Ma, C.* “Regioselective Synthesis of Fused Oxazepinone Scaffoldsthrough One-Pot Smiles Rearrangement Tandem Reaction”

ACS Combinatorial Science, 13,547–553, 2011.



【科研项目】

1.“惰性键活化的新型Smiles重排串联反应在杂环合成中的应用” (2016-2019)，国家自然科学基金。

2.“基于Smiles重排串联反应的并三环杂环体系的构建” (2012-2015)，国家自然科学基金。

3.“叶醇合成新工艺的开发” (2014-2015)，山东新和成药业有限公司 (横向)。

4.“几种异喹啉类天然产物及其类似物的合成及生物活性研究” (2010-2012)， 山东省自然科学基金重点项目。

5．“几种多药耐药逆转活性中药单体及其类似物的全合成及活性研究”（2009-2011），国家自然科学基金。

6．“抗寄生虫药吡喹酮的合成方法研究” (2008-2010)，山东省科技发展计划。

7.“噁嗪并异喹啉杂环有机分子的合成及生物活性研究” (2007-2009)，山东省自然科学基金重点项目。

8.“含异喹啉杂环化合物的设计, 合成及生物活性研究” (2006-2008)，山东省优秀中青年科学家科研奖励基金。

9.“哒嗪-1,4-噁嗪并异喹啉衍生物的设计, 合成及生物活性评价” (2005-2007), 教育部留学回国人员启动基金。

【科研成果】

【课题组】

硕士研究生：储向龙，戴朕，牛亚迪。

博士研究生：张泽远，刘欢欢，谢彩霞。

已毕业学生：辛亮，万年星，罗丽，张宏志，张伟，赵鑫，周利，张群，丁锴，李靖，展春景，刘艳丽，赵永梅，张鑫海，黄爱萍，李艳秋，牛晓毅，房帅，杨冰川，段田田，胡芳东，于小颖，范金皓。

【所获专利】

【联合培养情况】

本课题组与北京大学化学与分子工程学院有机所王剑波教授课题组联合培养博士研究生。

【拟招收研究生情况】

每年招收硕士、博士研究生各1-2名（包括工程硕士）。培养的研究生适合在高校、科研院所、企业等从事有机合成、药物合成方面的教学、科研及技术开发等工作。